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All product prices are in US dollars.
US Brand Name Bonefos
Generic Name Disodium clodronate
Other Brand Name Bonefos
Packing 60
Manufacturer Schering
Form Tablet
Strength 800mg
Country

  • 60 tabs 800mg $329.40
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Details

Introduction

The Disodium clondronate drug belongs to the family of bisphosphonates which are known to help in the building up of the bones. They reduce the osteoclastic activity inside the bones and bind to the hydroxyapatite crystals and thereby are able to provide the treatment in cases of bone resorption osteoporosis. The drug is used for the treatment of bony metastasis from some primary cancers and these are able to add further to the bone structure so that the bone pain and other complications can be prevented. The tablets are given to cancer patients, mainly to those suffering from multiple myeloma and breast cancer as they are mostly affecting the bone cancers.


Use

The drug has been used as a therapeutic pharmacotherapy for the bone complications of cancers such as multiple myeloma and breast cancer or any other metastatic bone cancer which reach the bones. Due to the cancer spread, there is loss of calcium from the bones, so that they are weakened and there is pain and fractures in the different parts, especially the spine and the leg bones and pelvis. This action is by the addition of calcium to the bone structures as the osteoclastic activity is stopped and the calcium is taken up by the bones.


Side effects

Tablet form of disodium clondronate can cause diarrhea, nausea and vomiting, and lead to decreased calcium level in the blood if sufficient calcium is not advised. Symptomatic hypocalcemia and allergic reactions are less common but can be seen in some people. bronchospasm can occur in few people although it is seen rarely. Even rarer side effects are kidney damage and osteonecrosis of jaw or fracture of femur and pelvic bones.


Contraindication

People who have low calcium levels should avoid taking disodium clondronate and even those who have high sodium levels as the sodium from the drug reaches the blood and can cause hypernatremia. Those who are allergic to the drug in any form and who have allergy to bisphosphonates should refrain from taking the drug. People who are taking other forms of bisphosphonate drugs shouldn't be given the drug as it will increase the total level of the compound in the body. If there is lower or reduced kidney function or decreased creatinine clearance, then the drug is to be stopped or not advised. In pregnancy and children, the drug is not proved to be good, so should not be given.


storage

Storage of the drugs should be done in temperatures below 25°C and the shelf life of the tablets is about 3 years.


Composition

The disodium clondronate drug of 800 mg contains 1000 mg sodium clondronate tetrahydrate which is equivalent to 800 mg of anhydrous sodium clondronate along with many other elements which help as excipients. There is also a film coating of the Bonefos tablets which are the brand name for disodium clondronate tablets of 800 mg. They come in blister packs of 60 tablets of 800 mg tablets.


Important Precautions

Patients with renal insufficiency should take special precautions before using disodium clondronate. Dental problems and low calcium levels in the blood should be first checked. Precautions regarding fractures of the femur and bones are to be kept in mind, before one prescribes these drugs. Pregnancy present or planning of pregnancy should be immediately reported to the physician.


Dosage and administration

The 800 mg dose tablet is taken in empty stomach in the early morning with fluids but not milk. After taking the drug, the patient should be straight for an hour or so and shouldn't chew or suck the tablet as it might irritate the esophagus. They should also not take any other food for one hour. One 800 mg tablet is prescribed on a daily basis and this should be taken only on doctors' prescription.