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All product prices are in US dollars.
US Brand Name Detrusitol
Generic Name Tolterodine
Other Brand Name Detrusitol
Packing 56
Manufacturer Pfizer
Form Tablet
Strength 1mg 2mg
Country India

  • 56 tabs 1mg $33.04
  • 56 tabs 2mg $48.70
Out of Stock. Please contact us for Availability.
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Details

Introduction

Tolterodine is a competitive muscarinic receptor antagonist specifically acting selectively in vivo with high affinity to receptors in the bladder than those of the salivary glands. One of tolterodine metabolites (5-hydroxymethyl derivative) has a pharmacological profile similar to that of the parent compound. Intense metabolism in individuals with this metabolite contributes significantly to the therapeutic effects.


Use

Treatment of overactive bladder with symptoms of urinary frequency and urgency accompanied by incontinence is cured by aid of Tolterodine.


Side effects

Tolterodine can cause mild or moderate anti muscarinic effects such as dry mouth, dyspepsia or decreased lacrimation. . Common (> 1 / 100): Autonomic Nervous System: dry mouth . Digestive, dyspepsia, constipation, abdominal pain, flatulence, vomiting . General-headache . Visual-dry eye . Skin-dry skin . Psychiatric, drowsiness, nervousness . SNC-parenthesis . Uncommon (<1 / 100) - autonomic nervous system: disorders of accommodation . General: chest pain . Rare (1 / 1000): General: allergic reactions . Urinary bladder retention . CNS: confusion


Contraindication

It is contraindicated in patients: urinary retention, uncontrolled narrow-angle glaucoma by, myasthenia gravis, a history of hypersensitivity to Tolterodine or recipients severe forms of ulcerative colitis, toxic mega colon.


storage

Keep away from children. Away from heat exposure, direct sun light and UV light. Must be kept stored at a temperature under 28 degree Celsius.


Composition

Tolterodine L-tartrate (1) 1 mg and 2 mg, equivalent to 0.68 mg and 1.37 mg tolterodine (Rinn).


Important Precautions

Tolterodine should be administered with caution in patients with: significant postvezicala obstruction at risk of urinary retention, gastrointestinal obstruction such as pyloric stenosis, kidney disease, and liver disease. The recommended dose is 1 mg 2 times a day, autonomic neuropathy, hiatus hernia. In patients under concomitant treatment with CYP3A4 inhibitors such as macrolide antibiotics (erythromycin and clarithromycin) or antifungal (ketoconazole, itraconazole and miconazole), treatment by means of this medicine will be made with caution until further information.


Dosage and administration

The recommended dose is 2 mg 2 times a day, except in patients with hepatic dysfunction, which recommended dose is 1 mg 2 times a day. If it installs annoying side effects, dosage may be reduced from 2 mg to 1 mg two times a day. In children, safety and efficacy have not been established. Therefore, to obtain complete information about this tablet you can search on internet. After administration, it is rapidly absorbed, Mean maximum concentrations of this and metabolite increase proportionally with dose for doses between 1 and 4 mg. Tolterodine is metabolized mainly by polymorphic CYP2D6 enzyme, resulting metabolite 5-hydroxymethyl which is pharmacologically active. Metabolism in individuals with intense plasma clearance of this is approximately 30 l / hour and half-life of 2 to 3 hours.