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All product prices are in US dollars.
US Brand Name Detrusitol SR
Generic Name Tolterodine l-tartrate
Other Brand Name Detrusitol SR
Packing 28
Manufacturer Pfizer
Form Capsule
Strength 4mg
Country India

  • 28 Capsule 4mg $52.36
Out of Stock. Please contact us for Availability.
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Details

Introduction

Tolterodine l-tartrate is competitive muscarinic receptor antagonist specifically acting selectively in vivo with high affinity to receptors in the bladder than those of the salivary glands. One of Tolterodine metabolites (5-hydroxymethyl derivative) has a pharmacological profile similar to those of the parent compound. Intense metabolism in individuals with this metabolite contributes significantly to the therapeutic effects.


Use

Treatment of overactive bladder with symptoms of urinary frequency and urgency accompanied by incontinence is cured by taking Tolterodine l-tartrate. The drug has an exceptional usage in the treatment of loss of urine. Some people may have this problem of urging of urine without any reason. This disease causes more thirst of water in a frequent manner. This medicine has direct control of urine loss. This drug is having interaction with Pharmacokinetic medicines to increase the effectiveness of therapy. It can interact with Concomitant to avoid side effects for the therapy treatments.


Side effects

Tolterodine can cause mild or moderate anti muscarinic effects such as dry mouth, dyspepsia or decreased lacrimation. . Common (> 1 / 100): Autonomic Nervous System: dry mouth . Digestive, dyspepsia, constipation, abdominal pain, flatulence, vomiting . General-headache . Visual-dry eye . Skin-dry skin . Psychiatric, drowsiness, nervousness . SNC-parenthesis . Uncommon (<1 / 100) - autonomic nervous system: disorders of accommodation . General: chest pain . Rare (1 / 1000): General: allergic reactions . Urinary bladder retention . CNS: confusion


Contraindication

Known hypersensitivity is noted for the tolterodine and its inactive ingredients. If you are having urinary retention then you should consult your doctors before taking the medicines. People who are having eye-related problems like glaucoma should not use this medicine. It has contraindications to muscle related problems like myasthenia gravis. You should not have ulcer and allergic reactions before taking the medicines. You should not share capsules to any one of your members in home. Tolterodine is contraindicated in patients: urinary retention, uncontrolled narrow-angle glaucoma by, myasthenia gravis, a history of hypersensitivity to Tolterodine or recipients severe forms of ulcerative colitis, toxic mega colon.


storage

Keep away from children. Away from heat exposure, direct sun light and UV light. Must be kept stored at a temperature under 28 degrees Celsius.


Composition

Each capsule of Tolterodine l-tartrate contains the active substance Tolterodine L-tartrate (SR 4) 4 mg.


Important Precautions

Tolterodine should be administered with caution in patients with: significant postvezicala obstruction at risk of urinary retention, gastrointestinal obstruction such as pyloric stenosis, kidney disease, and liver disease. The recommended dose is 1 mg 2 times a day, autonomic neuropathy, hiatus hernia. In patients under concomitant treatment with CYP3A4 inhibitors such as macrolide antibiotics (erythromycin and clarithromycin) or antifungal (ketoconazole, itraconazole and miconazole), treatment with Tolterodine will be made with caution until further information.


Dosage and administration

The recommended dose is 2 mg 2 times a day, except in patients with hepatic dysfunction, which recommended dose is 1 mg 2 times a day. If it installs annoying side effects, dosage may be reduced from 2 mg to 1 mg two times a day. In children, safety and efficacy have not been established. Therefore, to obtain complete information, you can search on internet. After administration, Tolterodine is rapidly absorbed. Mean maximum concentrations of Tolterodine and metabolite increase proportionally with dose for doses between 1 and 4 mg. Tolterodine is metabolized mainly by polymorphic CYP2D6 enzyme, resulting metabolite 5-hydroxymethyl which is pharmacologically active. Metabolism in individuals with intense plasma clearance of Tolterodine is approximately 30 l / hour and half-life of 2 to 3 hours.