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All product prices are in US dollars.
US Brand Name Engerix-B
Generic Name Hepatitis B surface Antigen (Recombinant)
Other Brand Name Engerix-B
Packing 1ml
Manufacturer GSK
Form Vial
Strength 20mcg
Country India

  • 20mcg 1ml $16.78
Out of Stock. Please contact us for Availability.
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Details

Introduction

The vaccine of hepatitis B surface antigen (recombinant) is used for the vaccination of people in order to prevent them from being affected by hepatitis B virus. The vaccine is to be given to people who are susceptible to get infected and in children, thereby allowing protection from the deadly disease of hepatitis B. This vaccine is not the treatment for the infection of the liver.


Use

The vaccine is used to prevent the hepatitis infection in people who are at the risk of exposure to the infection and likely to be exposed to blood and blood products as this is the most common mode of transmission of infection. People living in endemic areas or who travel to such regions should be administered with the vaccine. Health personnel who are dealing with patients having hepatitis infection should be provided with the hepatitis vaccine. Those people, who have already received the vaccination, can also be given a booster dose of engerix B.


Side effects

The common side effects are related to the local site injection reactions such as redness, pain, induration and erythema. Rare side effects which can be seen are pain and arthralgia and other musculoskeletal side effects. Nausea, vomiting, abdominal pain and serum transaminases are rarely seen. Although the CNS symptoms after the vaccine have been seen, yet they are very rare in people.


Contraindication

In people who are allergic or hypersensitive to any of the components of the vaccine should not be advised for the vaccine. People who are having acute febrile illness should not be administered with the vaccine.


storage

At temperatures of 2-8 deg C the vaccine is stored for 3 years from the date of manufacture and it is not allowed to freeze.


Composition

The engerix B is a hepatitis surface antigen type B which is available in the recombinant form. It is available as a suspension, which is in form of vial of 1 ml for adults and 0.5 ml for children and comes with a prefilled syringe. Each 1 ml of vaccine contains 20 mcg of protein which has 95% of surface antigen and adsorbed on aluminium hydroxide along with thiomersal as preservative.


Important Precautions

Immunodeficiency diseases are not absolutely contraindicated but precautions are required to be taken in such patients and they should be constantly monitored for any adverse reactions. Sufficient antibody should not be attained in these patients. The vaccine is never given intravenously and there should be enough medical back up, to protect against any adverse reactions due to the vaccination. Syncope or fainting attacks should be observed in case the vaccine is administered. The vaccine is not protective against other hepatitis infections apart from the type B. In pregnant females, nursing mothers and premature infants, the vaccine is to be avoided as sufficient clinical trials have not been done. The vaccine is not supposed to be mixed with other vaccines in the same syringe or in the same injection site. Operating machineries after vaccination is not advised.


Dosage and administration

The vaccine is meant to be given intramuscularly only and never to be given intravenously or by any other route. This vaccine should not be given in the same syringe as other vaccines or at the same site of other vaccination. The dose of the immunisation is 3 doses, starting from any month after birth and the next two doses are to be administered at 1 and 6 months after the initial dose. In children, the vaccine is given as 10 mcg of protein in 0.5 ml of vaccine. For the adults, 20 mcg of protein in 1 ml of vaccine is ideal in the same regimen. The vaccine is given intramuscularly at the deltoid region in adults and the anterolateral aspect of the thigh in neonates.