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US Brand Name Generic Aredia
Generic Name Disodium Pamidronate
Other Brand Name Pamidria
Packing 150ml, 300ml, 450ml
Manufacturer Cipla Limited
Form Vial
Strength 30mg , 60mg , 90mg
Country India

  • 30mg 150ml $169.00
  • 60mg 300ml $329.00
  • 90mg 450ml $489.00
Out of Stock. Please contact us for Availability.
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Details

Introduction

It is known with the generic name of Disodium Pamidronate is a bone resorption inhibitor that is used to treat patients with cancer that break down bone cells or spread to the bones. Disodium Pamidronate may also be used to treat patients with hypercalcemia brought about by bone cancer in the person's body.


Use

Disodium Pamidronate drug is indicated for patients with Paget's disease of the bone, hypercalcemia rooted from a malignancy and osteolytic bone metastases.


Side effects

Common side effects of disodium pamidronate include flu like symptoms (fever, chills, and headache), hypocalcemia, drowsiness or dizziness. Occasional side effects include stomach pain, mood changes, skin rash, red and sore eyes, bone pain, anemia, constipation or diarrhea, changes in blood pressure. Rare side effects include kidney problems and osteonecrosis of the jaw.


Contraindication

Disodium Pamidronate is contraindicated among patients with hypersensitivity to pamidronate or other biphosphates.


storage

The unopened vial of disodium pamidronate could last up to four years. Once opened and diluted, it can last up to 96 hours (4 days) at 25 degrees Celsius.


Composition

Disodium pamidronate is a white powder. It is soluble in water and in 2N sodium hydroxide. The 30 mg and 90 mg vial comprises of 30 mg and 90 mg of sterile, lyophilized disodium pamidronate and 470 mg and 375 mg of mannitol. Its active ingredients include mannitol, USP, and phosphoric acid.


Important Precautions

Disodium Pamidronate drug should not be given as an IV bolus; It should always be diluted and given as a slow intravenous infusion. Serum electrolytes, calcium and phosphate should be closely monitored. Patients with preexisting or predisposing renal disease undergoing continuous infusions of disodium pamidronate should have intermittent evaluations in the laboratory in relation to their kidney function. Patients with Paget's are at high risk for developing hypocalcemia. It is important that they take oral vitamin D supplement during the course of disodium pamidronate to prevent hycocalcemia. Disodium pamidronate should not be given to patients with other biphosphate medications because the effect has not been tested.


Dosage and administration

Among patients with Paget's disease, the recommended Disodium Pamidronate doses of 60 mg by slow IV push at a rate of 15 mg/hr. For patients with hypercalcemia rooted from a malignancy, the recommended dose is 60mg/hr. When calcium level is below 3.00mmol/L, give at 30mg, when plasma calcium is at 3.0-3.5 mmol/L infuse at 30-60mg, when plasma calcium is at 3.5-4.0mmol/L give at 60-90mg, when plasma calcium is at 4.0mmol/L give at 90 mg. Repeat at least every 2 to 3 weeks as necessary. Among patients with osteolytic bone metastases, slow IV influsion at 2 hours in breast cancer, 4 hours in multiple myeloma. Repeat every 3 to 4weeks.