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US Brand Name Claritin
Generic Name Loratadine
Other Brand Name Loraclear, Loratin
Manufacturer CADILA
Packing 10
Form Pill
Strength 10 mg

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Details

Introduction

Loratadine or commercially popular as Claritin, is a long-affecting antihistamine that lowers the effect of Histamine in the body. It is used for the treatment of allergy. It obstructs the H1 receptor and hence, put a hold on cells’ activation with H1 receptors by histamine. Histamine is basically a chemical that is responsible for causing multiple signs and symptoms of allergy.


Use

Loratadine is primarily used for the treatment the nasal as well as non-nasal symptoms of seasonal allergies such as sneezing, runny nose, itching of the nose and throat and watery eyes. It is also prescribed while the treating chronic urticaria, which is a kind of allergic skin rash. In addition, it may be used for certain other treatments.


Side effects

Some of the most commonly observed side effects are dry mouth, nervousness, mouth sores, sore throat, nosebleed, weakness, headache, diarrhea, stomach ache and red or itchy eyes. Other side effects that may call for immediate doctor attention are constant itching, hives, rash, hoarseness, wheezing, breathing problem, swelling of face, arms, throat, ankles, legs, eyes, lips and tongue.


storage

The ideal temperature to store Claritin Tablets ranges between 2° and 30°C or 36°and 86°F.


Composition

CLARITIN Tablets is composed of 10 mg micronized loratadine, an antihistamine, which is controlled orally and a few inactive ingredients like lactose, magnesium stearate and corn starch.


Dosage and administration

In case of adults, (including children above six years of age) the normal dose of Loratadine prescribed is 10 mg daily. Children below 6 years of age are prescribed Loratadine syrup.
As per the rules of administration of Claritin, the tablet should be placed on the tongue. It disintegrates rapidly and can be administered with or without water.


Overdosage

In case of overdose, symptoms such as fast or pounding heartbeat, headache, drowsiness, and strange body movements are seen. Instant medical attention should be contacted in case of overdose.


Clinical performance

Loratadine in tablet form on human histamine skin demonstrates an antihistaminic effect starting within 1 to 3 hours. It remains as long as 8 to 12 hours or excessively 24 hours at the maximum. No results regarding the tolerance to this effect post 28 days of dosing with Claritin have been noticed. As per the whole body autoradiographic studies conducted on rats and monkeys, radiolabeled tissue distribution studies in mice and rats, revealed that along with Loratadine its metabolites too, did not get through the blood-brain barrier. Repeated dose of Claritin to the hamster cheek pouch caused no local irritation.