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All product prices are in US dollars.
US Brand Name Generic Desferal
Generic Name Desferrioxamine
Other Brand Name Generic Desferal
Packing 5, 10
Manufacturer Novartis
Form Injection
Strength 500 mg
Country

  • 5 Vial 500 mg 5 Injection $279.00
  • 10 Vial 500 mg 10 Injection $1,175.00
Available online
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Details

Introduction

The drug Desferrioxamine is an iron-chelating agent that binds free iron in a stable complex, and preventing it from engaging in chemical reactions. Deferoxamine chelates iron from the intra-lysosomal ferritin and siderin forming ferrioxamine, which is a water-soluble chelate excreted by the kidneys and in the feces through the bile. This drug does not readily bind iron from hemoglobin, transferrin, myoglobin or cytochrome.


Use

The drug Desferal is usually indicated for the treatment of patients with acute iron intoxication and of chronic iron overload due to transfusion-dependent anemias.


Side effects

Contact your doctor immediately if you have any of the signs of an allergic reaction such as nausea or vomiting, hives, fever, joint or muscle pain, difficulty breathing, headache, swelling of your face, lips, tongue or throat. Also inform the patient that occasionally their urine may show a reddish discoloration. Stop using this medication and call your doctor at once if you experience any of these serious side effects which include fast heartbeats; blue lips, skin, or fingernails; severe, watery, bloody diarrhea with cramping; cough, wheezing, gasping, or other breathing problems; and stuffy nose.


Contraindication

The drug is contraindicated in those patients with known hypersensitivity to the drug. It is also contraindicated in patients who are having severe renal disease or anuria.


storage

Store the drug in a dry cool place. Do not freeze.


Composition

The drug is in the form of an injection with the strength of 500 mg and is stored in 5 or 10 ml vial.


Important Precautions

Before using this medication, it is important to tell your doctor or pharmacist about your medical history, especially about: kidney problems, diabetes, rheumatoid arthritis, and any fungal infection. If you are using this medication for aluminum poisoning, also inform your doctor if you have experienced or having seizures, decreased calcium levels in the blood and hyperparathyroidism. This drug may cause dizziness or blurring of vision. Instruct patient to avoid driving, using machinery, or doing any activity that requires alertness or clear vision.


Dosage and administration

This route is preferred and should be used for all patients who are not in shock. The initial dose to be administered is 1000 mg. This dose may be followed by 500 mg every 4 hours divided into two doses. Depending upon the response of the patient, subsequent doses of 500 mg may be administered every 4 to 12 hours. The total amount of the drug administered should not exceed to 6000 mg in 24 hours. This drug is not recommended for use in children less than 3 years old. Depending on your medical condition, this medication is injected directly into the muscle, under the skin, or into a vein as directed by your doctor. Your doctor may direct you to take vitamin C after using this medication for at least 1 month. Doing so, vitamin C will help replace the loss of vitamin C due to high iron levels and help the medication work to get rid of the excess iron. If you have a heart disease such as heart failure, tell your doctor before taking vitamin C while using this medication.