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US Brand Name Glucophage , Glucophage, Glucophage XR
Generic Name Metformin
Other Brand Name Glumet XR, Glyciphage, Zometh, Cetapin, Glycomet, Metfor, Metformin
Manufacturer Mano Pharma, Franco Indian Pharmaceuticals , WALLACE, Lupin, USV
Packing 10
Form Tablet
Strength 1000mg, 850 mg, 500 mg

Available online
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Glucophage or metformin is an oral diabetes medicine that is prescribed to maintain normal levels of blood sugar. It is given to people suffering from type 2 (non-insulin-dependent) diabetes. In some cases, it may be recommended in the combination of insulin or other medications, but it cannot type 1 diabetes.


Glyciphage (Metformin) is prescribed while the treatment of Type 2 diabetes. It helps patients to control their blood glucose and bring it within the targeted range by enabling the body to produce less glucose from the liver. Also, Glyciphage (Metformin) helps in lowering the blood fat levels and perhaps contribute to some loss in weight loss.

Side effects

Diarrhea, stomach upset, and symptoms of hypoglycemia or low blood sugar like lightheadedness, faintness, instability, or increased appetite are some of the common and manageable side effects of Glyciphage. However, slightly severe side effect is lactic acidosis. It usually, appears in the patients dealing with kidney or liver problems. Instant medical attention should be taken in case of lactic acidosis as it may be life-threatening.


Glyciphage should be maintained at room temperature below 25 ?C and away from the reach of light, moisture and children.


The main active component of Glucophage is Metformin Hydrochloride. The quantity of Metformin Hydrochloride in each generic formation is either 500mg or 850mg.

Dosage and administration

Patients are normally recommended to start with an 850 mg tablet twice a day or a 500 mg tablet three times a day. The medication can be taken with or after food. However, it is best to take Glucophage tablets in divided doses with meals. If control is attained in anticipated duration, the recommended dose may increase to a maximum of 3 g daily. Once control is gained, the dose is reduced gradually.


Overdose of Glyciphage may result in lactic acidosis. The symptoms of lactic acidosis are slow heart rate, cold feeling, breathing difficulty, weakness, and stomach ache, excessive sleepiness, feeling of being light-headed, muscle pain and blacking out. Immediate medical attention is needed to handle such condition.

Clinical performance

A double-blind, placebo-controlled, multicenter US clinical trial was conducted on multiple obese patients having type 2 diabetes inadequately controlled hyperglycemia. These patients were given GLUCOPHAGE (up to 2550 mg/day) for about 29 weeks. The results were satisfying. They showed remarkable reductions in fasting and postprandial plasma glucose (PPG) and hemoglobin A1C (HbA1c) of 59 mg/dL, 83 mg/dL, and 1.8%, respectively. It will be helpful to mention that Metformin is one of the most frequently prescribed antidiabetic drugs in the entire world, with United States, having over 48 million prescriptions registered in 2010 for its generic formulations.

Patient Information Sheet
Generic Glucophage, Metformin Tablet FORMULA : Each uncoated extended release tablet contains: Metformin Hydrochloride I.P. ………………….1000mg Excipients q.s. Type 2 Diabetes Mellitus is growing problem across the world. There is now strong evidence that intensive control of blood glucose can significantly reduce and retard the micro vascular complications of ... [Read More]