Metformin, Careprost, Sildenafil, Tadalafil

All product prices are in US dollars.
US Brand Name GLUCOVANCE
Generic Name Glibenclamide+Metformin
Other Brand Name Glucored , Glinil M
Packing 200
Manufacturer Cipla Limited
Form Tablet
Strength 5mg + 500mg

  • 10 tabs Glibenclamide 2.5mg Metformin HCL 400mg $1.70
  • 10 tabs Glibenclamide 5 mg Metformin 500mg $2.10
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Details

Introduction

Glibenclamide+Metformin are part of oral antidiabetics and parenteral, oral hypoglycemic agents. It is both oral diabetes medicines that help to control blood sugar levels. Glibenclamide+Metformin are used to treat type 2 diabetes in the person's body. Glibenclamide+Metformin help in stabilizing blood sugar levels as well as protect against heart diseases.


Use

Glibenclamide+Metformin uses are: Spasmophilia, chronic tetany, idiopathic, latent neuro-vegetative hyperexcitability, headache, chest pain, numbness, tremors, muscle cramps and contractions fascicular, biliary dyskinesia, in pregnant women, asthenia and hiperemotivi with magnesium deficiency, magnesium losses. Ament with cortisone, digitalis, diuretics, thyroid extracts.


Side effects

Related to metformin - Gastrointestinal symptoms (> 10%) such as nausea, vomiting, diarrhea, abdominal pain and loss of appetite, usually occur early in treatment and in most cases resolve spontaneously. To prevent these gastrointestinal symptoms, it is recommended that metformin be administered 2-3 times daily. Dose titration may improve gastrointestinal tolerability. Common: metallic taste (3% of cases). In some patients with hypersensitivity has been reported the appearance of a slight erythema. These cases are very rare (<0.01%). Lactic acidosis is rare (0.03 cases per 1000 patients / year). Glibenclamide Related: hypoglycemia, skin and mucosal reactions: itching, urticaria and maculopapular rash. There have been few reports of photosensitivity. In rare cases there was cutaneous or visceral allergic vasculitis. Gastrointestinal disorders: nausea, diarrhea, epigastric discomfort. Liver damage: there was an increase in liver enzymes, the possible onset of a cytolytic or cholestatic hepatitis, requiring discontinuation. Haematological disorders, reversible after discontinuation: leukopenia, thrombocytopenia, less frequently: agranulocytosis, hemolytic anemia, bone marrow aplasia, and pancytopenia. Hepatic porphyria and skin. Isolated cases of hyponatremia. Other laboratory tests modified: moderate increases in blood urea and creatinine. Disulfiram-like effect in combination with alcohol.


Contraindication

Hypersensitivity to metformin hydrochloride, glibenclamide, other sulfonylurea or any of the excipients, diabetes mellitus type I (insulin-dependent) diabetic ketoacidosis, diabetic pre-coma, kidney failure or renal dysfunction (eg serum creatinine over 135 mol / L in men and 110 mol / L in women), it is possible acute renal function impairment, such as dehydration, severe infection, shock, intravascular administration of iodinated contrast substances. Acute or chronic diseases that can cause tissue hypoxia such as cardiac or respiratory failure, myocardial infarction, shock, liver failure, acute intoxication with alcohol, alcoholism. Porphyria, nursing association with miconazole.


storage

Like any drug, Glibenclamide+Metformin must be kept out of reach of children. Storage should be at temperatures between 2 and 30 degrees Celsius. Do not consume Glibenclamide+Metformin drugs after the expiry date which is specified on the box or packaging tablets.


Composition

500 mg tablets and metformin hydrochloride 5 mg glibenclamide, CT. x 2, 4, 6 or 8 packs. x 15 CPR.


Important Precautions

Lactic acidosis is a metabolic complication rare but serious (high mortality in the absence of a rapid treatment) that may occur due to metformin accumulation. The incidence of lactic acidosis can and should be low in the evaluation of other risk factors, such as poorly controlled diabetes, ketosis, prolonged periods between meals, excessive alcohol intake, hepatic insufficiency and any condition associated with hypoxia. Because it contains a sulfonylurea, Glibenclamide+Metformin expose the patient to the risk of hypoglycaemic episodes. Treatment should be prescribed only if a rigorous program of patient meals (including breakfast). Factors favoring hypoglycaemia: refusal or (more frequently in the elderly) patient inability to cooperate, malnutrition, irregular or missed meals, periods of fasting or dietary changes, exercise and report inadequate intake from carbohydrates, kidney failure, severe liver failure, overdose of Glibenclamide+Metformin, certain endocrine disorders (thyroid failure, pituitary failure), concomitant drugs (miconazole, fluconazole, phenylbutazone).


Dosage and administration

The recommended Glibenclamide+Metformin dose is 2-3 cpr. / Day.