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US Brand Name Megapen
Generic Name Ampicillin / Cloxacillin
Other Brand Name Megaclox
Manufacturer CIPLA
Packing 15
Form Capsule
Strength 250/250mg

Available online
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Generic Megapen or Ampicillin belongs to penicillin group of drugs and acts as antibiotics to fight bacteria in the human body. Derived from the basic penicillin nucleus, generic Megapen works be interfering with bacteria’s cell wall in their formation stage that results in killing the sensitive bacteria and weakening the cell wall. The cell wall ruptures and eventually kills bacteria in the body.


Generic Megapen, Ampicillin or DiCloxacillin capsules are used for the infections treatment caused by bacteria. The medication is also used in the treatment of infections caused by susceptible strains of the designated organism. Besides these generic Megapen is also used in the treatment of genitourinary tract infections like gonorrhea, respiratory tract infections, gastrointestinal tract infections and meningitis.

Side effects

People taking generic Megapen might develop signs of allergic reactions or can face some side effects. Emergency medical help should immediately be taken in case of any side effects or in case of allergic reactions. Some of the common side effects of the medication include:

• Diarrhea • Fever & Sore Throat • Headache • Flu symptoms • Weakness Besides side effects patients might also develop signs of allergic reactions like hives and swelling in face, lips, tongue, and throat.


Generic Megapen is recommended to be stored between 15 to 30°C and must be kept in a tightly closed container. The medication must be kept away from sunlight, moisture and heat. Megapen must be kept out of the reach of children and pets.


The Generic Megapen or Ampicillin contains inactive ingredients like titanium dioxide, silica gel, lactose monohydrate, black iron oxide, and gelatin.

Dosage and administration

Generic Megapen capsules must be taken exactly as prescribed by the doctors. People should never overdose the intake of the medication or should take for the longer period than prescribed. The capsule is suggested to be taken in empty stomach so patients should make sure that they take them at least one hour before having anything. The ideal dose of the medication for the patients suffering from respiratory tract infections is 250 to 500 mg of capsules that should be taken at the interval of 6 hours. However the dose of the medication varies from individual to individual depending upon their problems and complications.


Overdose of the generic Megapen might lead to serious consequences and hence in case of overdose the medication should be discontinued and the patients must be symptomatically treated. Supportive measures must be adopted according to the consequences, as in patients with renal function impairment Ampicillin class antibiotics are removed by hemodialysis instead of peritoneal dialysis. Overdose symptoms that may appear in patients include: • Behavioral Change • Skin rash • Urinating problem • Seizure

Clinical performance

Clinical trial of generic Megapen has proved its efficacy and safety in majority of the people. However the course of medication should not exceed more than 14 days. The medication has 85 to 87 percent success rate. Clinical trial also required three criteria to be met prior transition from intravenous to oral antimicrobial therapy. The criteria are, minimum 72 hours gap between the two therapies, patients should have no fever for prior 24 hours and improvements in the signs and symptoms of infections.