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US Brand Name Zocor
Generic Name Simvastatin
Other Brand Name Simcard, Simlup, Simcard, Simlo, Starstat
Manufacturer Cipla, Stancare Pharmaceuticals Div. of Ranbaxy Labs., IPCA, MHRA UK, Lupin
Packing 10
Form Pills, Tablet
Strength 80 mg, 40 mg, 20 mg, 10 mg, 5 mg

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Details

Introduction

Simvastatin is basically a hypolipidemic drug that is used to reduce and control the level of cholesterol. Blocking the production of cholesterol in the body, it brings down the level of low-density lipoprotein (LDL) cholesterol and total cholesterol in the blood. It is widely used for diseases that are caused by high cholesterol in the body including heart disease, coagulating arteries, and severe conditions that may eventually cause stroke, heart attack and vascular diseases.


Use

Simvastatin is prescribed to patients to lower the increasing level of unwanted cholesterol and fats (such as LDL, triglycerides) in their body, while maintaining required cholesterol (HDL) in the blood. Simvastatin comes from the group of drugs called "statins." It brings down the rising quantity of cholesterol released by the liver, which eventually decreases the occurrence of heart attacks and strokes. The medication is prescribed with a proper and healthy diet plan, along with other important lifestyle changes that facilitate the affect of medication.


Side effects

The serious side effects may include: • Muscle pain, weakness with fever or flu symptoms • Dark colored urine.

Common side effects include:

• Constipation • Diarrhea • Nausea, irritability • Stomach ache and bloating • Gas


storage

Simvastatin tablets are maintained best between 5 and 30 C (41 and 86 F). Oral disintegrating tablets are to be maintained between 20 and 25 C (68 and 77 F).


Composition

Zocor, or Simvastatin prescribed for oral administration has 5 mg, 10mg, 20 mg, 40 mg or 80 mg of simvastatin. In addition it contains multiple other inactive ingredients such citric acid, hydroxypropyl cellulose, starch, talc, ascorbic acid, hypromellose, lactose, magnesium stearate, iron oxides, microcrystalline cellulose, and titanium dioxide. To preserve the tablet, Butylated hydroxyanisole is added.


Dosage and administration

Normally, the dosage range of Zocor is fixed between 5 and 80 mg per day. Patients dealing with the risk of CHD are recommended the dose is 20 to 40 mg once a day. Patients at risk of CHD because of diabetes, peripheral vessel disease, stroke or other cerebrovascular disease, should take 40 mg per day. For adolescents aging between 10 to 17 years, starting dose of 10 mg once a day in the evening is recommended. For patients with severe renal impairment, the starting dose is 5mgper day, with careful monitoring.


Overdosage

An overdose of Simvastatin will immediately show symptoms of fever and flu with muscle weakness and pain. Although overdose of simvastatin does not cause life-threatening symptoms, one must call for medical help as soon as possible.


Clinical performance

Epidemiological studies have demonstrated that elevated levels of total-C, LDL-C, as well as decreased levels of HDL-C are associated with the development of atherosclerosis and increased cardiovascular risk. A study conducted on 16 senior patients between 70 and 78 years of age taking ZOCOR (simvastatin) 40 mg perday, revealed an increment of about in 45% in the mean plasma stage of HMG-CoA reductase inhibitory activity. Other set of 18 patients aging between 18 and 30 years of age. Clinical study on the elderly, showed no overall changes in safety between elderly and younger patients.