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US Brand Name Zyrtec
Generic Name Cetirizine
Other Brand Name Cetcip, Cetrizet, Alerid
Manufacturer GSK, Alkem, Cipla
Packing 10
Form Tablet
Strength 10 mg

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Details

Introduction

Cetirizine is the fourth addition to the latest generation of medications for allergy categorized under the section of "non- sedating" antihistamines or histamine (H-1) receptor blockers. Reducing the level of Histamine in the body, it helps treating symptoms such as sneezing, watery eyes, itching, and runny nose. As placed with non-sedating antihistamines, it may cause less sedation than other antihistamine but it definitely more sedating when it comes to other known non-sedating antihistamines.


Use

Patients are prescribed Cetirizine by the doctors to lower down the comfortless effect of allergic symptoms including sneezing, running nose and itchy eyes. In addition, it may also be prescribed for the treatment of certain other problems.


Side effects

Some of the infrequently complained side effects are dry mouth, fatigue, jitteriness, nausea, headache, and sore throat. Around 14 percent of patients also complain of sleepiness or slight drowsiness. On children, stomach ache and vomiting can be the adverse effects. Immediate clinical help should be contacted in case of fast or irregular heartbeat, breathlessness and difficulty in urinating.


storage

The medication should be maintained in its original container. Tightly closed, you must keep it safe from the children and extreme heat and cold temperatures. It is best maintained at room temperature. Medication that has run beyond its mentioned expiry date should not be used.


Composition

Cetirizine prescribed for oral administration are chewable tablets described as purple round tablets. The strength normally ranges between 5 to 10 mg. The inactive ingredients present in the chewable tablets are artificial grape flavor, betadex, NF, magnesium stearate, blue dye, colloidal silicon dioxide, acesulfame potassium, lactose monohydrate, mannitol, microcrystalline cellulose, red dye (carmine) and natural flavor.


Dosage and administration

ZYRTEC (cetirizine) is typically available as 5 mg and 10 mg tablets. For adults and children over 12 years of age the initial dose recommended is of 5 mg or 10 mg per day. For Children in the age group between 6 to 11 years, the normally prescribed dose of ZYRTEC (cetirizine) is 5 mg or 10 mg once daily depending on severity of the symptom. The time of administration may be varied as per the need of the patient. For patients suffering from Geriatric and are 77 years of age and above, the prescribed quantity is a dose of 5 mg once daily. To children below 6 years, cetirizine is given in the form of syrup.


Overdosage

Instant symptoms revealed on taking overdose of Zyrtec are irritability, restlessness drowsiness. In certain cases, the patient may also collapse due to difficulty in breathing. If such a situation arises, one must immediately call for medical aid.


Clinical performance

Few patients using Zyrtec frequently have shown symptoms of somnolence. Hence simultaneous use of cetirizine with alcohol and other depressants must be eluded to stay away from reduction in alertness. As per the 2-year long carcinogenicity study in rats, cetirizine did not come up as carcinogenic at dietary doses up to 20 mg/kg. However, it did cause an augmented rate of benign liver tumors in males at a dietary dose of 16 mg/kg. On the other hand at 4 mg/kg dose, no boost in the occurrence of liver tumors was observed. In mice, Cetirizine resulted in slow gain of pup weight while lactation at an oral dose in dams of 96 mg/kg.