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All product prices are in US dollars.
US Brand Name Twinrix
Generic Name Hepatitis A virus, Hepatitis B virus surface antigen
Other Brand Name Twinrix
Packing 1
Manufacturer GSK
Form Syringe
Strength Hepatitis A virus 720 ELISA u, Hepatitis B virus surface antigen 20 / 1ml

  • 1ml for Adult $57.81
  • 0.5ml for Pead $32.38
Out of Stock. Please contact us for Availability.

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Details

Introduction

Twinrix is a vaccine containing Hepatitis A and Hepatitis B virus surface antigen which is given to prevent the infection by these two types of hepatitis viruses. These are considered quite dangerous for the patients, due to which the hepatitis virus vaccine is quite prevalent nowadays. Since transmission of hepatitis A and B viruses is through cut wounds, sexual transmission, or through oro-fecal routes, the vaccine is used to prevent infection in case of future exposure to the drug.


Use

For the prevention of hepatitis A and B infections in human being, the vaccine is given. It is administered to people who are prone to get the infections such as health workers, hospital staff, people who take care of patients having hepatitis infections, and those who come in contact with infected fluids.


Side effects

Mild symptoms are seen with the vaccine mostly common and these clear out within a short period of time. Some of the common side effects are soreness, redness and burning pain at the site of injection. Vomiting, fatigue, fever, headache, and general feeling of being sick are seen with the hepatitis vaccine. Diarrhea, cough, sore throat, sweating, chills, and muscle aches are also seen. Tingling sensation, generalised stiffness, visual changes, dropping eyelids and sagging facial muscles are also seen but less frequently. Allergic reactions are seen with the vaccine but are not very common.


Contraindication

Allergic reactions to the vaccine or any other component are a contraindication for the vaccine. In case of high temperature problems, the vaccine should be avoided. The vaccine should not be used if the packaging is torn, or if the expiry date has passed.


storage

It is stored at the temperature of 2-8 deg C in the doctor's chamber in the fridge or in pharmacy and should never be frozen. It should be kept out from the reach of children.


Composition

The hepatitis vaccine contains the killed hepatitis A virus and the surface protein of Hepatitis B virus. The vaccine contains 720 Elisa units of Hepatitis A and 20 mcg of Hepatitis B in a solution of 1 ml. There are other inactive ingredients used as excipients and do not contain any human blood or blood products.


Important Precautions

The vaccine is not recommended for post exposure prophylaxis. Since the immune status might not become sufficient, the drug is not to be given in people with impaired host defence. The vaccine should be administered subcutaneously and not intravenously. Pregnancy should be told to the prescribing doctor as the vaccine is not to be taken during pregnancy.


Dosage and administration

Hepatitis vaccine of strength 720/20 is given to adults over a period of 6 months and total of 3 doses. After the first dose is given on a certain date, the next two doses are given 1 month and 6 months from the first dose. A rapid schedule of 0, 7 and 21 days have been devised, for administering in people who need to travel to endemic areas of hepatitis. A booster dose of 1 ml containing the above amount of hepatitis vaccine is given at 12 months from the 1st dose. The vaccine is given in the upper arm muscle in adults, subcutaneously and should never be given intravenously.